DNM1 Research & Publications
We collaborate with leading researchers worldwide to advance scientific understanding of DNM1-related developmental epileptic encephalopathy.
DNM1 Research Publications
Explore our interactive database of DNM1 research publications, variants, and scientific findings — updated as new research emerges.
See ultrafast endocytosis in motion.
Dynamin-1 drives ultrafast endocytosis — the split-second membrane recycling that keeps synapses firing. This animation shows the mechanism our research community is working to understand, and ultimately treat.
Labs & investigators working on DNM1.
A curated map of scientists worldwide studying Dynamin-1 biology, DNM1 genetics, and related mechanisms — spanning structural biology, synaptic physiology, and disease modeling.
Michael Cousin, PhD
University of Edinburgh
Mouse models of DNM1 epilepsy and activity-dependent bulk endocytosis (ADBE) — one of our earliest and closest scientific collaborators.
View Lab →Wayne Frankel, PhD
Columbia University — led by Tristan Sands, MD
Founded the DNM1 gene therapy program at Columbia, now led day-to-day by Tristan Sands, MD, developing a knockdown-and-replace strategy for DNM1 genetic epilepsies.
View Lab →Phillip Robinson, PhD
University of Sydney / Children’s Medical Research Institute
DNM1 inhibitors, Dynamin-1xA isoforms, phosphorylation and calcineurin regulation, and the Dynamin-1xA/Endophilin interaction in ultrafast endocytosis.
View Lab →Shigeki Watanabe, PhD
Johns Hopkins University
Nanoscale structural dynamics of the dynamin helical scaffold at the moment of membrane fission during ultrafast endocytosis.
View Lab →Yuuta Imoto, PhD
St. Jude Children’s Research Hospital
Uses high-speed atomic force microscopy and fluorescence imaging to capture the nanoscale, squeeze-twist dynamics of the dynamin helix at the instant of membrane fission.
View Lab →Matthew Weston, PhD
Virginia Tech — Fralin Biomedical Research Institute
Studies the DNM1 “fitful” mouse model and G239A-linked synaptic transmission defects and neurodegeneration.
View Lab →Click any investigator for details. Know a DNM1 lab that should be listed here? Let us know.
Scientific collaborators driving DNM1 discovery.
Professor Michael Cousin
University of Edinburgh
Drug repurposing and gene editing strategies targeting the GTPase domain of Dynamin-1.
View Profile →Professor Wayne Frankel
Columbia University
RNAi knockdown gene replacement strategy targeting the middle domain of the DNM1 protein.
View Profile →Rare Disease Translational Center
The Jackson Laboratory
Humanized mouse models under development — the first ever created for DNM1-related epilepsy.
View Center →Join our scientific network.
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