For Drug Developers & Researchers
DNM1 Structural Biology & Therapeutic Strategies
Explore the 3D structures of wild-type human Dynamin-1, understand the dominant negative disease mechanism, and discover the therapeutic approaches under development for DNM1 epilepsy.
Structural Biology
Human DNM1 PDB Structures
Key experimentally determined structures of human Dynamin-1. Click any structure to explore it interactively in 3D.
⚠️ Note: All structures below are human DNM1 (neuronal dynamin). DNM1L/DRP1 and DNM2 have been excluded. 3SNH uses an assembly-deficient mutant for crystallization purposes but represents the best full-length wild-type reference.
Full-Length / Near Full-Length
3SNH — Wild-Type Reference ⭐
Crystal structure of nucleotide-free human Dynamin-1. Full 4-domain architecture: GTPase domain, bundle signalling element (BSE), stalk, and pleckstrin homology (PH) domain. The landmark reference structure for DNM1.
Oligomeric / Helical Polymer Structures
6DLU ⭐ Best Resolution Oligomer
Cryo-EM of GMPPCP-bound human DNM1 polymer on membrane in constricted state. 3.75Å resolution — highest resolution oligomeric structure available.
6DLV — Super-constricted State
Cryo-EM of GTP-bound human DNM1 polymer in super-constricted state on membrane. Shows the final pre-fission conformation.
7AX3 — Two-Start Helix
Super-constricted two-start dynamin-1 filament with GMP-PCP in the absence of lipid. Most recent oligomeric structure, revealing unique two-start helical symmetry.
GTPase / Domain-Specific Structures
5D3Q — GDP-bound State
GTPase-BSE fusion dimer complexed with GDP. Provides a snapshot of the post-hydrolysis state, completing the full nucleotide cycle picture.
6S9A — GTPase-BSE Dimer
Artificial GTPase-BSE fusion dimer of human Dynamin-1. Used to characterize the motor module and estimate power stroke forces via smFRET.
3ZYS — Early Polymer Structure
Human dynamin-1 ΔPRD polymer stabilized with GMPPCP at 12.2Å. First cryo-EM polymer structure showing G domain dimers form between tetramers in sequential rungs.